Welcome to the Minc Lab

Institut Jacques Monod (Paris, France)

How do cells determine their shape and size?

How do cells decide in which direction to grow or where to divide?

How might cells sense their geometry?

Héliciane and Hiro presenting at the Roscoff Jacques Monod meeting

Both Héliciane and Hirokazu are presenting novel data at the Jacques Monod meeting: "Actin and microtubule cytoskeleton: bridging scales from single...

Lab Retreat in Versailles

   The lab spent a rainy yet fantastic day in the Versailles Castle. Beyond touristic visit we had interesting debates on scientific...

New paper on yeast polarity accepted in Molecular Biology of the Cell

This manuscript by Armin Haupt, establishes that there are gradients of membrane charges linked to the distribution of the lipid phosphatidylserine,...

Daria Bonazzi, Laureate of the L’Oréal-UNESCO Prize For Women in Science

Daria, a former PhD from the lab was awarded a prestigious prize from L'oreal for her outstanding...

Seminar at Physics and Biology of The Cell

Nico presents recent work on cell shape and early embryogenesis, at this international conference held at Ecole Polytechnique.

Fundamental research on cell morphogenesis

The goal of our research is to elucidate how cells establish their particular morphology and internal organization in order to perform their given functions. We aim to take a broad and multidisciplinary approach to this problem and use different organisms to identify general principles controlling cell morphogenesis. One hallmark of our work is to integrate and develop state of the art quantitative approaches, such as micro-fabrication, mathematical modeling and image analysis tools to address basic questions in morphogenesis. To reach these goals we combine expertise from different fields including chemistry, biology and physics. The current main research area of our team include: 

1. The study of cell division positioning during early embryogenesis and in developing tissues. In these projects we perform experimental work using sea urchin embryonic cleavages as a quantitative model system. We also develop computational models to understand mechanisms of spindle orientation in other developing tissues or embryos of different species.

2. The study of the emergence of cell polarity and cell shape in single-celled organisms. In these projects we use the rod-shape fission yeast Schizosaccarhomyces pombe and perform quantitative experiments to elucidate how spatial order emerges in these model unicellular eukaryotes.

Minc Lab | Fundings

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